A drug for pancreatic cancer shows immense promise, but we shouldn’t forget research in the field is a story of small victories

It is unlikely that we will ever declare a final victory over cancer. Governments have often promised it: from Nixon’s 1971 “war on cancer” to the 2016 Obama‑Biden plan to fight and cure it “once and for all” and Sajid Javid’s 2022 “war on cancer” initiative in the UK. But framing it this way can obscure how real progress is made: not in stunning routs, but in stalling and turning back the advance of this terrible condition – often in simply giving people more time to live.

Several such breakthroughs, and a bigger one that could transform the treatment of multiple kinds of cancer over the next decade, emerged at last week’s American Society of Clinical Oncology meeting in Chicago. As the Guardian revealed, there is a new jab effective against head and neck cancers in some patients, and a new immunotherapy that could spare bladder cancer patients invasive and life-changing surgery. Most significantly, there is a new drug called daraxonrasib, which doubled survival time for pancreatic cancer patients in a recent clinical trial.

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The new James Bond-themed videogame 007 First Light had a budget of 1.3 billion Danish krone — a little more than USD $202 million, reports IGN, citing a report from Denmark's public service broadcaster. "Denmark's TV 2 said that makes 007 First Light the most expensive entertainment product in the country's history" — and the game "still has some way to go before breaking even." 007 First Light is estimated to have sold 2.2 million copies, generating $150 million in revenue... The only official sales data we have comes from developer IO Interactive, which said that 007 First Light had become the fastest-selling game in the company's history, shifting 1.5 million copies in its first 24 hours... The impressive sales milestone was achieved without the aid of the Nintendo Switch 2 version, which is due out this summer. The James Bond adventure is also the highest rated IOI game ever, with an 87 on Metacritic... The developer has said it wants to make a trilogy of James Bond games. Game-tracking company Alinea Analytics tweeted their estimates that 55.1% of sales were on PS5, 33.1% on Steam, and 11.8% on Xbox (Xbox console, Windows, and cloud combined). And Polygon reports that new downloadable game content was announced Friday.

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Anchor who was fired accuses editor-in-chief of requesting changes to report that video of shooting did not support

Fired CBS 60 Minutes anchor Scott Pelley has accused editorial management at his old network of interfering with a broadcast segment looking at an immigration officer’s killing of Minneapolis protester Renee Good in January.

The veteran broadcaster, who was recently dismissed from the show, said CBS News’s editor-in-chief Bari Weiss had sent an email to his supervisor requesting changes be made soon before the airing of the segment in question.

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Science magazine reports: For decades, string theory promised a "theory of everything" that described all particles and forces as tiny vibrating strings. Physicists hoped it could also solve one of the field's deepest problems: reconciling quantum mechanics with gravity. But as string theory grew increasingly elaborate — and experimentally unreachable — many physicists lost hope. Now, some researchers are revisiting the theory from first principles. In a paper in press at Physical Review Letters, Clifford Cheung, a physicist at the California Institute of Technology, and colleagues lay out a small set of assumptions about the universe and show that they inevitably give rise to string theory.... Cheung's study, along with another one posted to arXiv in January, starts with two reasonably conservative assumptions: that the probabilities of all possible outcomes of an event add up to 100%, and that the laws of physics are consistent for observers moving at different speeds. Each group then posits additional assumptions that have not been borne out by observations. Cheung's analysis invokes "ultrasoftness," the idea that the probability of certain particle interactions drops off at a particular rate at high energies. The second study, led by University of Michigan physicist Henriette Elvang, instead assumes "supersymmetry," a maximal coupling between matter and forces. Both groups conclude the only theory that can satisfy their assumptions is one that looks like string theory... Cheung and Elvang stress that their aim is not to prove the inevitability of string theory. "I don't have a dog in the fight; I just work here," Cheung says. Rather, the goal is to explore the space of possible theories under rigid constraints — regardless of whether they reflect reality... The one thing the researchers all agree on is that the field would benefit from more alternative models to string theory. Cheung sees the agnostic, bottom-up exploration as a step in that direction. "You can either give up on the problem because it's too culturally toxic, or you can ask: If you want to find an alternative, what do you need?" he says. "Now, we know exactly what to do." Thanks to Slashdot reader sciencehabit for sharing the article.

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The Socceroos playing on football’s biggest stage in my adopted country would normally have me racing to book tickets. Not this year

Is “USA! USA! USA!” a more fundamentally obnoxious chant than “Aussie! Aussie! Aussie! Oi! Oi! Oi!”? As an Australian who has spent most of the last 15 years living in the United States and is now a permanent resident, the Socceroos’ World Cup group match against the USA raises some questions. Has my adopted nation dethroned my homeland as the world’s foremost exponent of being unconscionably terrible to immigrants? And on a more personal level … who do I support here?

Well, look, OK, there’s really only one answer to that second question. I’m not an especially patriotic type, but if anything does bring out my Australian-ness, it’s the World Cup – perhaps because it’s one of the few events at which we can still claim to be underdogs. And now, two decades after I rose at dawn to watch Australia’s dreams dashed by the intersection of Lucas Neill’s leg and Fabio Grosso’s general vicinity, I find myself living in a country hosting the tournament.

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Search enters second day after Saturday shooting that wounded 12, two reported in critical condition, police say

Organizers of a festival in the historic center of Toledo, Ohio, have cancelled planned events on Sunday as police continue the search for at least two shooters who wounded 12 people a day earlier.

The Toledo police deputy chief, Joseph Heffernan, said the shooters were “probably shooting at each other” when gunfire erupted just after 5.30pm near the Old West End festival, an annual gathering of live music and architectural home tours.

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A "growing wave" of Reddit's "promoted posts" are sending U.S. and European audiences to money-stealing scams that impersonate major news organizations including the BBC, the Financial Times, and The Guardian, according to new findings from Bitdefender Labs. "Domains are short-lived and rapidly rotated to evade detection," they write, noting that the impersonating sites apparently even use language "to falsely imply that the investment platform had been reviewed, approved, or vetted" by the legitimate site they're impersonating: The campaign promotes fake AI-powered investment platforms such as Wencoin STX, Warrior Coin AI, and Nevo Coin, using fabricated celebrity endorsements, cloned news websites, fake interviews, and invented financial success stories to lure victims into depositing money. Researchers Andrea Olariu and Emanuel Puscasu have identified multiple promoted Reddit posts masquerading as legitimate financial or breaking news stories. Some ads claimed that: — NVIDIA and OpenAI were "creating the future" — Heathrow police discovered hundreds of thousands of pounds in cash — Governments and banks were allegedly trying to "hide" a revolutionary AI investment platform — European regulators were "silencing" articles about AI trading systems Some Reddit ads delivered in video format, including what appeared to be a deepfake BBC news segment featuring a news anchor presenting fabricated financial headlines... Examples observed by researchers included: — Fake BBC pages discussing "$20 billion conversations" tied to AI investments — Fraudulent Financial Times articles about Heathrow airport cash seizures — Fake Guardian stories claiming governments were trying to suppress coverage of Wencoin STX or Nevo Coin The pages featured fabricated interviews, fake profit screenshots, manipulated banking documents, false testimonials, and even fictional journalists or business editors designed to make the scam look legitimate. In many cases, the content sought to create a sense of exclusivity or conspiracy, suggesting that banks, regulators, or governments were trying to suppress public access to the investment platform... Our researchers found that after users clicked links embedded within the fake Guardian articles, they were redirected to a registration form allegedly used to create a "Nevo Coin" investment account. The form requested personal contact information, including the victim's name, email address, and phone number. To increase pressure and encourage immediate action, the page warned that registration availability was limited, claiming that once all spots were filled, new user registrations would be suspended. And in the final stage, they're asked to deposit money...

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Organizers cancel planned events as search for at least two shooters enters second day after Saturday shooting

Organizers of a festival in the historic center of Toledo, Ohio, have cancelled planned events on Sunday as police continue the search for at least two shooters who wounded 12 people a day earlier.

The Toledo police deputy chief, Joseph Heffernan, said the shooters were “probably shooting at each other” when gunfire erupted just after 5.30pm near the Old West End festival, an annual gathering of live music and architectural home tours.

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(idiom) can't help but; involuntarily (HSK 7-9)

Lots of us have– thanks to repetative stress injuries– developed mobility issues that we have to work around when using computers. Maybe it’s a trackball instead of a mouse, or …read more

At least 12 people were wounded in a shooting near the Old West End festival in Toledo, Ohio, on Satuday. Toledo's deputy police chief, Joe Heffernan, said two people were in a critical condition. No arrests have been made and the search for the suspects is continuing

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