Evidence is piling up that GLP-1 drugs can treat addiction. We must learn from the way that obesity has been stigmatised

In the years since so-called weight-loss jabs entered widespread use, there have been reports that these drugs may not just reduce food cravings, but in fact cravings and desires full-stop. Earlier this month, a study using large-scale data from US veterans undergoing diabetes treatment suggested that those on the jabs were less likely to develop addictions to a wide range of drugs. Patients already using substances appeared about half as likely to suffer overdose or drug-related death if they were taking the jab as well.

This is an exciting avenue for future research. These medicines work partly on satiation and reward centres in the brain. It is likely that problematic food and drug cravings share a similar biological basis, and next-generation medicines may be more powerful or more targeted to one or the other. But, in the meantime, we should expect that existing weight-loss drugs will end up recommended (or prescribed off-label) for addiction treatment. This should make us rethink our approach to these remarkable medicines.

Colossal Biosciences’ CEO says its work follows a ‘moral obligation’ while critics say it’s ‘tech bro’ hype that could undermine conservation

Can and should we resurrect animal species that have been extinct for thousands of years? Such weighty, existential questions were once the preserve of science fiction but are now being played out within an unassuming brick building in a Dallas business park.

Colossal Biosciences, valued at $10.2bn after raising hundreds of millions of dollars in funding from investors including celebrities spanning from Tiger Woods to Paris Hilton, has provoked a stampede of acclaim as well as denunciation after announcing last year it had made the dire wolf, a species lost from the world for more than 10,000 years, “de-extinct” via the birth of three new pups.

Colossal Biosciences’ CEO says its work follows a ‘moral obligation’ while critics say it’s ‘tech bro’ hype that could undermine conservation

Can and should we resurrect animal species that have been extinct for thousands of years? Such weighty, existential questions were once the preserve of science fiction but are now being played out within an unassuming brick building in a Dallas business park.

Colossal Biosciences, valued at $10.2bn after raising hundreds of millions of dollars in funding from investors including celebrities spanning from Tiger Woods to Paris Hilton, has provoked a stampede of acclaim as well as denunciation after announcing last year it had made the dire wolf, a species lost from the world for more than 10,000 years, “de-extinct” via the birth of three new pups.

Tommy Thompson refused to give up the location of 500 missing coins found in 1988 in a historic shipwreck

A US treasure hunter who was imprisoned for 10 years after refusing to reveal the location of missing gold coins has been released from prison, without officials apparently ever learning where that gold is.

Tommy Thompson – a renowned salvager who in 1988 found the long-lost, so-called Ship of Gold near South Carolina – was freed from federal prison on 4 March, records and reports recently indicated.

Democrat says Congress ‘doing nothing’ may embolden president to attack countries such as Cuba and North Korea

Democratic US senator Cory Booker has criticized both his own political party as well as its Republican counterpart for being “feckless” in ceding congressional war powers to Donald Trump, saying that their decision could embolden the president to unilaterally attack Cuba, North Korea and other countries.

“I’m going to be one of those Democrats [who] say I think both parties have been feckless in allowing the growth of the power of the presidency,” Booker said on Sunday on CNN’s State of the Union.

Oil could pass 2008 record of $147.50 a barrel as damage and field closures risk compounding supply shock caused by Iran war

About 20 miles off the coast of Iran lies the source of the petrostate’s economic lifeblood and the latest target of US military aggression: an 8 sq mile coral island through which nine in every 10 barrels of Iranian crude passes each day.

The US president’s decision to launch a weekend attack on Kharg Island, the home of Iran’s processing hub and the heart of its economy, is an unsurprising counterstrike to the Iranian regime’s ongoing chokehold on the oil market’s trade artery.

The luxury property surge fuels growth in Miami, but a poll finds many residents weighing an exit over housing and living costs

To a casual observer, everything in south Florida’s real estate garden is looking rosy. There’s a “gold rush” in Miami as ultra-wealthy buyers snap up mega-mansions and luxuriously appointed condos as soon as they hit the market; and the Guardian has also reported recently on the “Mamdani effect” of elite New Yorkers arriving in the sunshine state with bulging pocketbooks in search of a high-priced escape from the city’s new mayor.

Yet alongside the boom, there are rumblings of a more troubling parallel reality. Undoubtedly, the billionaire class is helping to pump even more dollars into an already thriving Florida economy. But as prices rise and the less affluent find everything from housing and insurance to gas and groceries increasingly expensive, many are considering doing something about it.

Oil could pass 2008 record of $147.50 a barrel as damage and field closures risk compounding supply shock caused by Iran war

About 20 miles off the coast of Iran lies the source of the petrostate’s economic lifeblood and the latest target of US military aggression: an eight square mile coral island through which nine in every 10 barrels of Iranian crude passes each day.

The US president’s decision to launch a weekend attack on Kharg Island, the home of Iran’s processing hub and the heart of its economy, is an unsurprising counterstrike to the Iranian regime’s ongoing chokehold on the oil market’s trade artery.