A research team found "extensive changes" on brain scans of 13 young women taking GLP-1 drugs, reports the Washington Post: Within only a few months, the brain connections in the salience network, which helps target attention, had multiplied... ["We didn't expect to see this effect, and we really don't know what it means," said an assistant professor assisting the research.] Ozempic and other GLP-1 drugs were initially understood as a metabolism breakthrough: medicines that act like hormones to control hunger, blood sugar and weight. But as researchers probe deeper into how the drugs work, early evidence suggests that GLP-1s may also be reshaping parts of the brain. Tens of millions of people are now taking the medications worldwide, turning what began as an obesity and diabetes treatment into what could be modern medicine's largest unplanned neuroscience experiments... Long before Oprah Winfrey and social media influencers helped popularize GLP-1 drugs, physician-scientist Lorenzo Leggio was studying them as a possible addiction treatment... Several major studies examining GLP-1 drugs on nicotine dependence, opioid- and cocaine-use disorders, gambling addiction and binge eating are also underway. "It's very exciting times, but we don't fully understand how it works," Leggio said... As evidence has grown that inflammation, metabolism and mental health may be far more connected than scientists once believed, researchers have become intrigued by patients who say GLP-1 drugs appear to ease anxiety, compulsive thinking and emotional distress. Daniel Drucker, a University of Toronto researcher and GLP-1 drug pioneer who receives funding from several drugmakers, said researchers are investigating the medications across a variety of psychiatric and neurological conditions, though none are approved for them. "We have so many anecdotal reports: They were treated for blood sugar and then they felt much happier. Or they took one dose of the drug and their brain fog cleared," he said. The article suggests social media complaints "raise deeper questions about what, exactly, these drugs are changing. "If GLP-1s alter the brain systems involved in reward, craving and motivation, researchers wonder, where is the line between quieting a person's destructive impulses and reshaping personality itself?"

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Four were part of seven-person group that had traveled to US to ascend North America’s tallest mountain

Three people have died after falling while climbing Alaska’s Mount McKinley, according to officials. A fourth climber has been rescued.

The four were part of a seven-person group that had traveled to the United States to ascend Mount McKinley, also known as Denali, North America’s tallest mountain, according to information released by the Latvian Mountaineering Association.

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Security company Okta shot up 30% Friday, reported CNBC, while data platform provider Snowflake jumped 50% this week. They see it as part of a larger trend where software stocks "soared this week," signaling "some companies are navigating their way through AI disruption better than Wall Street expected" and that investors "may have been too quick to declare the end of software with the emergence of AI. Even as AI displaces certain tools and job functions, many software companies continue to show growth, assisted by their own AI products..." The "SaaSpocalypse" may not be over. But for now at least, fears of software's demise have cooled... The iShares Expanded Tech-Software exchange-traded fund rose 8% this week and closed May up 21%, the best monthly performance for the ETF since October 2001. Back then it was a brief rebound during the dot-com bust, while the current rally comes as concerns about the impact of AI ripple across the sector. Software names have been hit particularly hard over the past year due to the boom in so-called vibe coding, with users able to now build apps and websites in minutes thanks to offerings from Anthropic, OpenAI and others... Elsewhere in the software space, Atlassian climbed 26% for the week and ServiceNow surged over 20%, while Shopify, Workday and Asana each gained at least 14%.

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In first suit over conditions at Texas’s Camp East Montana, plaintiffs allege ‘dangerous and abusive’ environment with ‘abhorrent’ medical care

The first lawsuit relating to the largest immigration detention facility in the US was filed early on Saturday against Immigration and Customs Enforcement (ICE), accusing the agency of “dire” conditions that severely violate the human and constitutional rights of those locked up at the camp in Texas.

A clutch of legal organizations is suing via a class action complaint, listing four detainees as plaintiffs for themselves and on behalf of all those currently held as civil detainees at Camp East Montana or who will be held there in the future.

“abhorrent medical and mental health care”;

“inappropriate use of force”;

“indiscriminate use of solitary confinement”;

“terrible, rotten, spoiled and inadequate” food;

“outbreaks of disease”;

“unsanitary living conditions”;

“sexual harassment by guards”.

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joint; node / (bound form) section; segment / solar term (one of the 24 divisions of the year in the traditional Chinese calendar) / seasonal festival / (bound form) to economize; to save / (bound form) moral integrity; chastity / classifier for segments: lessons, train wagons, biblical verses etc / knot (nautical miles per hour) (HSK 2)

As long as you remain angry at the city, you can ignore the candidate’s lack of experience or inability to articulate actual policy

I vote by mail in every election these days, as is my right as a mostly lazy natural-born American citizen. Fill in a few bubbles with black ink, chuck the thing into the nearest dropbox, and consider myself a functioning member of society for a brief moment. Now that my son is old enough to ask me coherent questions about my daily life, he was highly interested in what the hell I was doing as I marked the form. “I’m voting,” I said tersely, lest I divert my attention fully from the bubble-filling. “Don’t vote for Spencer Pratt, daddy,” he responded. “I hear he’s a jerk.” The word seems to be spreading.

Every local TV station and streaming app is turgid and bloated with political ads these days. My son might be old enough to ask me who I’m voting for, but he’s not old enough to understand why. That doesn’t stop campaigns from serving him countless commercials pleading with him to consider (or reconsider) a certain candidate. He’s now nominally aware of allegations of sexual misconduct against LA city controller Kenneth Mejia (which Mejia has denied) and the Orange County congressman Ken Calvert’s run-in with a sex worker. What a joy it is to be a parent in 2026.

Dave Schilling is a Los Angeles-based writer and humorist

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There is little sign of clarity in the closing stretch of a campaign season for governor, Congress and LA mayor

Californians are frustrated and underwhelmed heading into Tuesday’s primary election, where voters will eliminate all but two candidates in the volatile race for governor, the messy battle for Los Angeles mayor and a series of congressional contests that could determine control of the US House in November.

With days left before the 2 June primary, there is little sign of the clarity that typically emerges in the closing stretch of a contested California campaign season. The race to succeed term-limited Democratic governor Gavin Newsom appears to have settled into a tight three-way contest among Democrats Xavier Becerra and Tom Steyer and Republican Steve Hilton, while voters in Los Angeles remain divided over whether to stand by embattled mayor Karen Bass or entertain a challenger.

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Along with layer lines, FDM printers are notorious for being neither air- nor water-tight due to the countless very small gaps between the layers. This is very unfortunate if you …read more

Plane landed in Wisconsin and ‘unruly passenger’ was taken into custody before flight continued to Minnesota

A United Airlines flight bound for Minneapolis from Chicago was reportedly diverted after an “unruly passenger” tried to breach the cockpit late on Friday.

The FBI and police responded to reports of a security concern with the passenger, who was detained by police at the Dane county regional airport in Madison, Wisconsin.

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President in ‘excellent’ health, despite ‘lower leg swelling’ and hand bruising after fourth hospital visit in second term

Donald Trump has been grappling with “lower leg swelling” as well as “benign” hand bruising but remains in excellent health, the US president’s physician said in a memo released by the White House.

Citing the results of a recent examination, the memo from Dr Sean Barbabella said Trump “remains in excellent health, demonstrating strong cardiac, pulmonary, neurological and overall physical function”.

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Experts say AI firm’s engagement with Vatican risks creating ‘feelgood’ discourse that lacks critical examination

Why did Anthropic’s founder sit beside the pope during a warning about AI?

In the first major written teaching of his papacy, Pope Leo XIV took artificial intelligence to task. The pontiff delineated the technology’s most concerning threats to humanity: replacing workers, accelerating war and exploiting the environment. At a ceremony honoring the holy teaching the day of its release at the Vatican, the pope was flanked by an unusual guest speaker: Anthropic co-founder Chris Olah, one of the people behind the AI boom so worrying Leo.

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Endangered snow leopard had leg amputated and capybara died at Mario Tabraue’s controversial roadside facility

An endangered clouded leopard had a leg amputated and a capybara died following botched breeding attempts at a controversial Miami roadside zoo owned by a convicted drug trafficker featured in the Netflix documentary Tiger King.

Federal wildlife inspectors found multiple other violations during a March inspection at Zoological Wildlife Foundation (ZWF), including dilapidated, insecure or unsafe housing conditions for wild animals, filthy cages, and water and food contaminated with algae and dead insects.

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