Scientists "have made a discovery that may help prevent some people from developing lung cancer," reports the New York Times, noting that lung cancer "kills more people worldwide than any other cancer." A team of more than 80 researchers working across four continents have identified a set of proteins in the blood that accurately predict lung cancers more than five years before diagnosis. The scientists also found early evidence that an existing anti-inflammatory drug could significantly reduce lung cancer risk in people with elevated concentrations of these proteins, which they linked to inflammation. More research is needed before a test based on these proteins could be ready for use in patients. And scientists would still need to run a randomized trial to determine whether the drug prevents lung cancers. Still, outside experts said the findings, which were published on Thursday in the journal Cell, offer a promising starting point toward a long-held public health goal... Led by Dr. Swanton, Dr. Tej Pandya, a Ph.D. student, and other researchers took a set of 48,000 blood samples from the UK Biobank and used machine learning to identify 14 proteins associated with the development of lung cancer. When the researchers looked at the presence of those proteins and also took into account a patient's age, smoking status and history of lung disease, they were able to predict who would develop lung cancer more accurately than the best risk assessment models currently in use... Using mouse and cell models, the scientists showed that these proteins increased when a specific inflammatory pathway was activated. Smoking and air pollution can activate that pathway. This adds to the evidence that it isn't just genetic mutations caused by smoking, pollution or other factors that are driving lung cancers. Rather, Dr. Swanton said, the findings suggest that "smoke causes mutations and inflammation, which together cause cancer." They also found that the signature was increased in people who later developed chronic obstructive pulmonary disease and pulmonary fibrosis, pointing to a common inflammatory environment upstream of all three diseases.
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Kristen Gonzalez, a state senator who authored the bill, said moratorium would target ‘hyperscale’ datacenters over 20MW
New York moved closer toward becoming the first US state to enact a moratorium on large datacenters this week. On Thursday, the state legislature approved a one-year ban on the facilities powering the AI boom.
The measure now heads to Kathy Hochul, the governor, who will decide whether to sign it into law. The Guardian spoke to a state senator in the wake of the historic vote about authoring the bill and the wider US backlash against datacenters.
Continue reading...As detainees go on hunger strike over conditions at Delaney Hall, relatives describe concern for loved ones’ wellbeing
In mid-May, Elder Guerra was showering inside the Delaney Hall immigration detention facility when he slipped and fell.
Guerra, a Guatemalan immigrant, has been locked up in the New Jersey jail for nearly five months. He was arrested by federal Immigration and Customs Enforcement (ICE) officials in Newark in January while helping a friend move his snowed-in car. Officers had approached and asked a few questions, according to a relative who spoke with the Guardian.
Continue reading...Technology secretary promises to support people whose jobs are swept away by automation
Liz Kendall has insisted Labour will make artificial intelligence “work for workers”, and not abandon people whose jobs are swept away by its rapid advance.
With public fears mounting about the impact of AI on employment, particularly for young people, the technology secretary claimed that the government could shape the way it is adopted.
Continue reading...Plan backed by Shark Tank’s Kevin O’Leary had footprint reduced but concerns remain over its health impacts
Utah residents have teamed up with a progressive non-profit organization to sue over an under-development AI datacenter backed by celebrity investor Kevin O’Leary, claiming the planned Stratos project facility “irrevocably” cuts off citizens’ rights by not allowing sufficient public input.
Filed by the Alliance for a Better Utah and five unnamed residents of the Box Elder county area where the center is being developed, the lawsuit comes as Shark Tank co-host O’Leary agreed to scale back the physical footprint for the project.
Continue reading...Knicks edge Spurs 105-104 to take 2-0 NBA finals lead
Wembanyama made costly turnover in final seconds
No team has won finals after losing first two at home
San Antonio star Victor Wembanyama could barely remember the details of the late-game miscues that cost the Spurs in their agonizing 105-104 loss to the New York Knicks in Game 2 of the NBA finals on Friday.
The Spurs used a 14-0 scoring run to erase a 14-point fourth-quarter deficit and briefly took a one-point lead before it all fell apart.
Continue reading...An upcoming vote in a few weeks on America's cryptocurrency "Clarity Act" is "rattling Wall Street and consumer advocates," reports CNN, with its proposal to regulate the bulk of crypto markets through America's Commodity Futures Trading Commission. "It allows crypto companies to operate, at long last, in compliance with U.S. rules, rather than what they have been doing — essentially running their businesses within a patchwork of state and federal legal gray areas." Even for Jamie Dimon, the banking titan who's not known to mince words, it was a surprising shot across the bow when he described a fellow financier as "full of sh*t." "No one's gonna bow down to this guy or that company," Dimon told Fox Business last week. "This guy" being Brian Armstrong, and "that company" being cryptocurrency exchange Coinbase. The Dimon-Armstrong tension isn't new, but it is boiling over publicly as the Senate inches closer to a floor vote on the crypto industry's No. 1 legislative priority, known as the Clarity Act. Dimon, a longtime crypto skeptic, broadly supports crypto regulation but takes issue with a provision in the Clarity Act that would allow companies like Coinbase to "effectively pay interest on deposits... without the protection they should have." The spicy comment about Armstrong came after Dimon rattled off other concerns about the Clarity Act, including what he sees as its insufficient anti-money-laundering and know-your-customer safeguards that banks have had in place for decades... "If (Armstrong) takes deposits like a bank, he should have bank rules," Dimon said in the Fox Business interview... The immediate concern from banks (and many consumer advocates) is that crypto exchanges like Coinbase would, in the grand tradition of Silicon Valley innovation, lure customers in with huge rewards and then phase those benefits out over time. Deposits in a crypto exchange are also not insured by the federal government the way bank deposits are, but that's the kind of fine print that customers tend to overlook until it's too late. JPMorgan Chase spokesperson Trish Wexler underscored that the bank wants the bill to pass, with some "fixes," like prohibiting rewards on stablecoin holdings and strengthening anti-money-laundering guardrails. Coinbase's CEO responded in an interview with Politico: Armstrong pointed to restrictions on rewards paid to idle cryptocurrency balances and disclosures on stablecoins as part of a handful of policies included in the bill to appease the banking industry's requests. "I think it'd be good for the banks," Armstrong said of the bill. "It would be great for crypto companies as well ... Hopefully we can get past the absolutisms and just see if we can get this bill over the finish line." But CNN notes concerns about weaving cryptocurrency — "a historically self-contained financial system prone to stomach-churning booms and busts" — more deeply into America's traditional finance infrastructure: "It's not just a crypto story, it's a broad deregulation of our securities markets story," Hilary Allen, a law professor at American University who specializes in banking and cryptocurrency, said in an interview. And that should concern everyone, Allen says, even if they have no investments at all, because "if we get a financial crisis in this space... no one comes out of that unscathed."
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Iran attacks American bases in Gulf states after Washington shoots down drones and strikes Iranian radar sites
Bahrain has said Iran fired ballistic missiles and drones at it and Kuwait, hours after the US and Iran exchanged strikes over the Gulf, the latest in a series of flare-ups that threatened to break the fragile ceasefire.
Air raid sirens rang out on Saturday in Bahrain and people were told to move to a safe location and await further instructions. Kuwait’s military said it was intercepting drones and missiles launched at the country.
Continue reading...Elon Musk firm plans the biggest stock market launch in history – but experts have flagged potential downsides
It’s being billed as the biggest stock market launch in history. Shares in Elon Musk’s SpaceX are poised to be released on 12 June with a valuation of $135 (£100.84). The company plans to sell 555.6m of them, which means it will raise $75bn from the sale.
On Friday, it was reported that up to a quarter of the shares could be reserved for individual investors, rather than funds and banks. This is a bigger share than is typically the case in a large initial public offering (IPO).
Continue reading...An official trailer dropped this week for Tomb Raider: Legacy of Atlantis. It's "a full-blown remake of the original 1996 Tomb Raider game," reports Kotaku, "rebuilt from the ground up using Unreal Engine 5." Developed by Flying Wild Hog (with assistance/guidance from longtime Tomb Raider studio Crystal Dynamics), "it will also make some changes to puzzles, combat, platforming..." The game's Steam page acknowledges that AI-assisted tools were used during development "to support some early exploration and temporary development content," but that any AI-assisted assets were "either replaced or refined by humans in order to maintain the creative and artistic vision of the development team." In a statement to Eurogamer, Crystal Dynamics clarifies that they "leverage" AI tools "to help our teams iterate on ideas faster and more efficiently, while ensuring that all finished content in the final product is human-crafted." (But are they considering AI-assisted assets "refined" by humans as "human-crafted"?) Polygon reports that "The early response to the news has been mixed to negative on the Tomb Raider subreddit, ranging from vague hopes that the generative-AI craze will simply go away to grim resignation that this is the future of game development." Beyond labor concerns, art theft worries, and environmental issues, the most straightforward reason AI art has been unpopular is that many players find it hideous. We'll find out for sure whether Tomb Raider: Legacy of Atlantis' use of AI is particularly blatant when it comes out in February 2027. Its release date is February 12, 2027 on PS5, Xbox Series X/S, Switch 2, and PC.
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